If he were in the U.S. Senate now, would Scranton collaborate with Democrats? This falls into the world of conjecture, but it’s likely that he would keep his distance from the likes of Mitch McConnell or John Boehner.
Actually the Republican and Democratic parties collaborated quite a bit well into the 20th century. They had to, because both parties were populated by both liberals and conservatives. Republicans and Democrats crossed party lines to advance their causes.